Development of peptides that suppress the interaction between RANK and RANKL.
  Mature osteoclast cell development is inhibited through suppression of proteins involved in the differentiation of osteoclast precursor cells.
   
 
9 mer cyclic peptide
   
     
  Calculation of binding constants
Binding constants between the peptide and RANKL is measured using Biacore.
   
     
  Rabbit BRA (Bone Resorption Assay)
Amount of C-telopeptide measured from the media inside the vehicle-only treated well is set as 100, and the inhibition activity by the peptide-based compound is calculated asa percentage. The experiment was performed twice. E-64, an irreversible cysteine protease inhibitor, was used asa comparative study drug and positive control (reference).
   
 
Optimization studies are being performed at present, including in vivo efficacy, pharmacokinetics, and stability tests. The synthetic peptide as an osteoporosis inhibitor has applications in various indications, and Peptron intends to collaborate with partners or license the compound for drug development.